Category: Neurology
NEJM – Mogamulizumab (Anti-CCR4) in HTLV-1–Associated Myelopathy
February 8, 2018 N Engl J Med 2018; 378:529-538 DOI: 10.1056/NEJMoa1704827 BACKGROUND Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1–associated myelopathy–tropical spastic paraparesis (HAM–TSP) as well as adult T-cell leukemia–lymphoma...
Approach to a Patient with Diplopia in the Emergency Department.
J Emerg Med. 2018 Feb 6. pii: S0736-4679(17)31211-8. doi: 10.1016/j.jemermed.2017.12.045. [Epub ahead of print] Approach to a Patient with Diplopia in the Emergency Department. Margolin E1, Lam CTY1. Author information Abstract BACKGROUND: Diplopia can be the...
Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.
Lancet. 2017 Dec 6. pii: S0140-6736(17)32451-0. doi: 10.1016/S0140-6736(17)32451-0. [Epub ahead of print] Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Nath S1, Koziarz A1, Badhiwala JH2, Alhazzani W3, Jaeschke R3, Sharma S1, Banfield L4, Shoamanesh A5, Singh S1, Nassiri F2, Oczkowski W5, Belley-Côté...
NEJM – Multiple Sclerosis (review article)
Multiple sclerosis is widely prevalent, and yet a cure is not available! This exciting review from the New England Journal of Medicine has beautiful pictures and goes over more recent insights of mechanisms and...
NEJM – Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
Abstract BACKGROUND: The effect of endovascular thrombectomy that is performed more than 6 hours after the onset of ischemic stroke is uncertain. Patients with a clinical deficit that is disproportionately severe relative to the infarct volume may benefit from...
NEJM – New Therapies for Spinal Muscular Atrophy
Spinal muscular atrophy type 1 (SMA1) is a progressive, monogenic motor neuron disease with an onset during infancy that results in failure to achieve motor milestones and in death or the need for mechanical...
NEJM – 2 articles on Neurosurgery for Epilepsy, clinical trial and histopathology
Paper 1 – Surgery for Drug-Resistant Epilepsy in Children Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials. In this single-center trial, children...
NEJM – Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy
This is a breakthrough article in the field of Neurology! Cerebral adrenal leukodystrophy is an X-linked disease with a single gene mutation. I carries a dismal prognosis for the majority of patients, who can...
NEJM series on Stroke – Patent Foramen Ovale: close, or not to close?
This is a comeback for PFO closure! This series comprised of 3 trial published in the New England Journal of Medicine that enrolled patients after stroke with PFO and either left-to-right shunt or atrial...
