Prevalence of seizures in brain tumor: A meta-analysis
Christine Audrey 1, Kheng-Seang Lim 2, Rafdzah Ahmad Zaki 3, Si-Lei Fong 1, Chet-Ying Chan 1, Thinisha Sathis Kumar 4, Vairavan Narayanan 4, Chong-Tin Tan 1
Affiliations expand
- PMID: 36274423
- DOI: 10.1016/j.eplepsyres.2022.107033
Abstract
Objectives: Prevalence of seizures in brain tumors vary substantially between studies even with similar histopathological types. We aimed to identify the seizure prevalence of the commonest types of brain tumors.
Methods: Systematic computerized search of PubMed, Embase, and Web of Science were performed. The meta-analysis of pooled prevalence and 95 % confidence interval (CI) for tumor-related seizures were calculated by using a random effect model. Based on the 2014 epilepsy definition, a mean seizure prevalence of 60 % is used to indicate high seizure prevalence in this study.
Results: 74 studies that reported seizure prevalence with 23,116 patients were included in this meta-analysis. These tumors has higher seizure incidence rate (at least 60 %) with pooled prevalence of 63 % for adult with low-grade astrocytoma (95 % CI: 57-68 %), 65 % for oligodendroglioma (95% CI: 57-72 %), 72 % for oligoastrocytoma (95 % CI: 67-77 %), 81 % for ganglioglioma (95 % CI: 66-97 %) and 94 % for DNET (94 % CI: 83-100 %).
Conclusion: This study highlights the type of brain tumors that carry a high seizure prevalence. Screening for subtle seizures and early management of seizures may be beneficial in patients with low-grade astrocytoma (adult), oligodendroglioma, oligoastrocytoma, ganglioglioma or DNET brain tumor.
Keywords: Brain tumor; Meta-analysis; Prevalence; Systematic review.
Copyright © 2022 Elsevier B.V. All rights reserved.
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