J Stroke Cerebrovasc Dis 2022 Jul;31(7):106538.
doi: 10.1016/j.jstrokecerebrovasdis.2022.106538. Epub 2022 May 3.
Analysis of Factors Associated with Hemorrhagic Transformation in Acute Cerebellar Infarction
Lanjing Wang 1, Lijun Liu 1, Yanhong Zhao 1, Di Gao 1, Yanhong Yang 1, Min Chu 2, Jijun Teng 3
Affiliations expand
- PMID: 35523054
- DOI: 10.1016/j.jstrokecerebrovasdis.2022.106538
Abstract
Objectives: Hemorrhagic transformation (HT) is a frequent and severe complication of ischemic stroke. This study aimed to evaluate the factors associated with the occurrence of HT in patients with acute cerebellar infarction.
Materials and methods: A total of 190 patients, 141 male (74.2%) and 49 female (25.8%) with mean age 61.84 ± 12.16 years, who were admitted within 72 h of acute cerebellar infarction onset from January 2017 to March 2021 were retrospectively recruited. The multivariate logistic regression analysis was used to evaluate the independent influent factors for HT and receiver-operating characteristic (ROC) curve was applied to calculate the predictive value of those factors for HT in patients with acute cerebellar infarction.
Results: 37 out of 190 recruited patients (19.47%) had HT within 14 days after acute cerebellar infarction onset. The incidence rates of HT occurring within 3 days, 3-7 days and 7-14 days were 13.5%, 40.5% and 45.9%, respectively. Results of the multivariable logistic regression analysis indicated that atrial fibrillation (AF) (OR 6.196, 95% CI 1.357-28.302, P = 0.019), infarct diameter (OR 5.813, 95% CI 2.932-11.526, P < 0.001), white matter hyperintensity (WMH) (OR 2.44, 95% CI 1.134-5.252, P = 0.023) were independent risk factors for HT in acute cerebellar infarction, while lymphocyte count (OR 0.319, 95% CI 0.142-0.716, P = 0.006) showed an independently protective effect.
Conclusions: Infarct diameter, AF and WMH are independent risk factors for HT in patients with acute cerebellar infarction, while the lymphocyte count is a protective factor.
Keywords: Cerebellar infarction; Hemorrhagic transformation; Neuroimaging; Risk factors.
https://pubmed.ncbi.nlm.nih.gov/35523054/
Editor do blog: Julio Pereira – Neurocirugião – São Paulo CRM/SP 163.113 Site para Consulta: https://www.julio-pereira.com/ Consultório: (11)99503-8838 (WhatsApp) / (11)4200-2300 Atuando no Hospital Sírio-Libanês e na BP – A Beneficência Portuguesa de São Paulo. neurocirurgião beneficência portuguesa & neurocirurgião são paulo & neurocirurgião sírio-libanês
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