The purpose of this study was to verify whether the prevalence of intracranial aneurysm (IA) in patients with acoustic neuroma is greater than that in age- and sex-matched controls and to evaluate the independent risk factors related to the occurrence of IA.
Higher Prevalence and Age Susceptibility of Intracranial Aneurysm in Patients With Acoustic Neuroma
Honghai You 1, Yue Bai 2, Ting Yu 1, Tiefa Zeng 1, Nan Huang 3, Wenzhong Mei 1, Changzhen Jiang 1, Dezhi Kang 1, Xiyue Wu 1, Fuxiang Chen 1Affiliations expand
- PMID: 33224100
- PMCID: PMC7667236
- DOI: 10.3389/fneur.2020.591526
Free PMC article
Abstract
Introduction: The purpose of this study was to verify whether the prevalence of intracranial aneurysm (IA) in patients with acoustic neuroma is greater than that in age- and sex-matched controls and to evaluate the independent risk factors related to the occurrence of IA. Methods: We retrospectively analyzed 231 patients diagnosed with acoustic neuroma at our institute between 2015 and 2019 and 489 controls from the medical examination center. Cerebrovascular angiography was acquired from all subjects to assess the presence of IA or not. The prevalence of IA and risk factors associated with a higher IA occurrence were compared, respectively. Results: Cerebral aneurysms were detected in 23 patients (10.0%) and 11 controls (2.2%). The prevalence of IA was significantly different between patients with acoustic neuroma and controls (p < 0.001), and the difference was mainly reflected in the age of 50 and above. In the subgroup analysis, there were distinct differences in several clinical features including age, hypertension, and tumor volume, and cystic change between patients coexisted with IA or not. However, age was a unique independent risk factor for coexistence of IA in patients with acoustic neuroma after multivariate logistic regression (OR 1.050, 95% CI 1.008-1.093, p = 0.019). Conclusions: Our results demonstrate that patients with acoustic neuroma have a higher prevalence of IA than the general population. Older age is correlated with greater occurrence of IA in these patients.
Keywords: acoustic neuroma; cerebrovascular angiography; intracranial aneurysm; prevalence; risk factor.
Copyright © 2020 You, Bai, Yu, Zeng, Huang, Mei, Jiang, Kang, Wu and Chen.
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