Percutaneous radiofrequency ablation of painful spinal metastasis: a systematic literature assessment of analgesia and safety.

 2018 Dec;34(8):1272-1281. doi: 10.1080/02656736.2018.1425918. Epub 2018 Jan 17.

Percutaneous radiofrequency ablation of painful spinal metastasis: a systematic literature assessment of analgesia and safety.

Abstract

PURPOSE:

Radiofrequency ablation (RFA) is the most common percutaneous technique applied to treat painful spinal metastasis; however, experience in this field is somehow still limited. A systematic literature research was performed to understand the effects of RFA in terms of analgesia and safety.

MATERIALS AND METHODS:

Inclusion criteria for the studies were as follows: (1) randomised controlled or non-randomised studies with a prospective or retrospective design; (2) population made up of adults with spinal metastasis; (3) spinal metastasis treated with RFA alone or in combination/comparison with other treatments; (4) studies reporting about patients’ pain before and at least one time-point following RFA; and (5) English-language studies.

RESULTS:

Seven hundred and thirty-three articles were screened and 8 (4 prospective, 4 retrospective) matched the inclusion criteria. Study population ranged between 10 and 92 patients across studies. Five out of eight studies reported a highly effective pain management (≥4 points of pain reduction between baseline and the last time-point available); 2/8 studies reported moderate results (≥2 points of pain reduction between baseline and the last time-point available). All studies combined RFA with cement augmentation in the vast majority of patients (40-100%) or metastasis (94-95.8%). Grade I-IIIa neural complications were reported in up to 16% of the cases and were always managed conservatively or with steroids.

CONCLUSIONS:

RFA, combined with vertebral augmentation in most of the cases, is effective and safe in achieving short- to mid-term (from 1 week to 6 months) analgesia in patients affected by painful spinal metastasis.

KEYWORDS:

Bipolar; metastasis; radiofrequency ablation; spine; vertebral augmentation

PMID:

 

29308694

 

DOI:

 

10.1080/02656736.2018.1425918

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