NEJM series on Stroke – Patent Foramen Ovale: close, or not to close?

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This is a comeback for PFO closure!

This series comprised of 3 trial published in the New England Journal of Medicine that enrolled patients after stroke with PFO and either left-to-right shunt or atrial aneurysms. All 3 clinical trials showed the benefit of PFO closure on this patient population in comparison with antiplatelet therapy or anticoagulation.

Enjoy the read at NEJM:

http://www.nejm.org/doi/full/10.1056/NEJMoa1705915

http://www.nejm.org/doi/full/10.1056/NEJMoa1610057

http://www.nejm.org/doi/full/10.1056/NEJMoa1707404