Analysis of Non-Modifiable Risk Factors for Intracranial Aneurysm Rupture in A Large

Full article access for Neurosurgery subscribers at

BACKGROUND: The risk factors predictive of intracranial aneurysm rupture remain incompletely defined.

OBJECTIVE: To examine the association between various non-modifiable risk factors and aneurysm rupture in a large cohort of patients evaluated at a single institution.

METHODS: A retrospective analysis of patients admitted to a cerebrovascular facility between January 2006 and 2010 with a primary diagnosis of cerebral aneurysm. Aneurysms were divided into two groups: unruptured or ruptured. The dome diameter, aspect ratio (AR), location, sidedness, neck morphology, and multiplicity were entered into a central database. A full model was constructed and systematic removal of the least significant variables was performed in a sequential fashion until only those variables reaching significance remained.

RESULTS: We identified 2347 patients harboring 5134 individual aneurysms, of which 34.90% were ruptured and 65.09% were unruptured. 25.89% of aneurysms with a dome diameter < 10 mm and 58.33% of aneurysms with a dome > 10mm were ruptured on admission (p<0.0001). 52.44% of aneurysms with an AR > 1.6 presented following a rupture (p<0.0001). The highest incidence of rupture (69.21%) was observed in aneurysms with an AR > 1.6, dome diameter < 10mm, and a deviated neck. Deviated neck-type aneurysms had a significantly greater incidence of rupture than classical neck-type aneurysms (p<0.0001).

CONCLUSION: An AR > 1.6, dome diameter > 10mm, a deviated neck, and right-sidedness are independently associated with aneurysm rupture.

Full article access for Neurosurgery subscribers at

Sent with MobileRSS for iPhone

Júlio Leonardo B. Pereira


Neurosurgery from Brazil.To provide neurosurgeouns with the most timely comprehensive and relevant clinical information to improve patient care; we offer a web site where patients can view our patient-level information for free

You may also like...

Leave a Reply

%d bloggers like this: