Reducing the risk of venous thromboembolism in patients with acute stroke: more evidence from the CL

In 2009, the CLOTS (Clots in Legs Or sTockings after Stroke) Trial Collaboration reported a study of prevention of deep vein thrombosis (DVT) in 2518 patients who were immobile due to a recent (<1 week) acute stroke. They were randomised 1:1 to the intended use or avoidance of thigh length graduated compression stockings. After about 7–10 days, compression Doppler ultrasound was performed by a technician from whom the allocation was concealed. DVT, the primary outcome, was similar (10.0% vs 10.5%) in the two groups. However, ulcers, blisters, skin breaks and necrosis were significantly more common (5% vs 1%) in those who had stockings. Compliance with the allocated treatment was high (97% vs 95%).1

At the time the CLOTS Trial Collaboration was reported, work was near completion on NICE guidance for venous thromboembolism (VTE) prophylaxis in all hospitalised patients. Given the concerns regarding the administration of heparin in recent stroke,…


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