Publication year: 2011
Source: The Lancet Neurology, In Press, Corrected Proof, Available online 6 September 2011
Elizabeth, Leroux , Dominique, Valade , Irina, Taifas , Eric, Vicaut , Miguel, Chagnon , …
Background: Suboccipital steroid injections can be used for preventive treatment of cluster headache but few data are available for the efficacy of this approach in clinical trials. We aimed to assess efficacy and safety of repeated suboccipital injections with cortivazol compared with placebo as add-on therapy in patients having frequent daily attacks. Methods: In our randomised, double-blind, placebo-controlled trial at the Emergency Headache Centre in Paris, France, we enrolled adults aged 18–65 years with more than two cluster headache attacks per day. We randomly allocated patients to receive three suboccipital injections (48–72 h apart) of cortivazol 3·75 mg or placebo, as add-on treatment…
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