Emergency Reversal of Clopidogrel in the Setting of Spontaneous Intracerebral Hemorrhage

Publication year: 2011
Source: World Neurosurgery, Volume 76, Issues 1-2, July-August 2011, Pages 100-104
Peter G., Campbell , Sanjay, Yadla , Anish N., Sen , Jack, Jallo , Pascal, Jabbour
Objective: To compare outcomes in the setting of spontaneous intracerebral hemorrhage (ICH) in patients taking aspirin (acetylsalicylic acid [ASA]) versus patients taking clopidogrel before hospitalization. Methods: Patients admitted to the neurosurgical service with a spontaneous ICH while taking an antiplatelet agent were prospectively identified and retrospectively reviewed. Two groups of 28 consecutive patients taking ASA or clopidogrel on admission were ultimately evaluated. Results: Patients in the clopidogrel group had a mean age of 72.6 years, and patients in the ASA group had a mean age of 65.8 years (P = 0.04). Patients taking clopidogrel before hospitalization were significantly more likely than patients taking ASA to…


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