Late occurrence of drop metastasis to the spine in a case of esthesioneuroblastoma
Journal of Neurosurgery: Spine, Volume 0, Issue 0, Page 1-5, Ahead of Print.
Abigail J. Rao, M.D., S. Humayun Gultekin, M.D., Edward A. Neuwelt, M.D., Hector R. Cintrón-Colón, B.S., and Brian T. Ragel, M.D. Esthesioneuroblastoma is an aggressive neuroectodermal tumor that originates from the olfactory mucosa and often recurs locally. Distant metastasis of esthesioneuroblastoma has been described, but there are few reports of drop metastasis to the spinal cord. Here, we report a case of multiple drop metastases to the cervical, thoracic, and lumbar regions of the spinal cord that occurred 18 years after resection and radiotherapy of the original anterior cranial fossa lesion. There was no evidence of local recurrence. The symptomatic lesion was treated with resection and adjuvant chemotherapy. The options available for treatment of this disease are summarized with a review of the few reported cases of spinal metastasis of esthesioneuroblastoma.