Freezing of gait: moving forward on a mysterious clinical phenomenon

Publication year: 2011
Source: The Lancet Neurology, Volume 10, Issue 8, August 2011, Pages 734-744
John G, Nutt , Bastiaan R, Bloem , Nir, Giladi , Mark, Hallett , Fay B, Horak , …
Freezing of gait (FoG) is a unique and disabling clinical phenomenon characterised by brief episodes of inability to step or by extremely short steps that typically occur on initiating gait or on turning while walking. Patients with FoG, which is a feature of parkinsonian syndromes, show variability in gait metrics between FoG episodes and a substantial reduction in step length with frequent trembling of the legs during FoG episodes. Physiological, functional imaging, and clinical–pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG. Medications, deep brain stimulation,…

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