Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging — Haldorsen et al. 32 (6): 984 — American Journal of Neuroradiology Free PDF
Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging — Haldorsen et al. 32 (6): 984 — American Journal of Neuroradiology
Sumary: CNS lymphoma consists of 2 major subtypes: secondary CNS involvementby systemic lymphoma and PCNSL. Contrast-enhanced MR imagingis the method of choice for detecting CNS lymphoma. In leptomeningealCNS lymphoma, representing two-thirds of secondary CNS lymphomas,imaging typically shows leptomeningeal, subependymal, dural,or cranial nerve enhancement. Single or multiple periventricularand/or superficial contrast-enhancing lesions are characteristicof parenchymal CNS lymphoma, representing one-third of secondaryCNS lymphomas and almost 100% of PCNSLs. New CT and MR imagingtechniques and metabolic imaging have demonstrated characteristicfindings in CNS lymphoma, aiding in its differentiation fromother CNS lesions. Advanced imaging techniques may, in the future,substantially improve the diagnostic accuracy of imaging, ultimatelyfacilitating a noninvasive method of diagnosis. Furthermore,these imaging techniques may play a pivotal role in planningtargeted therapies, prognostication, and monitoring treatmentresponse.