Cochrane: Surgery for primary supratentorial intracerebral haemorrhage

Surgery for primary supratentorial intracerebral haemorrhage

Prasad, K, Mendelow, AD, Gregson, B.

Cochrane Database Syst Rev. 2008; (4):CD000200.

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There is considerable international variation in the rate and indications of surgery for primary supratentorial intracerebral haematoma, reflecting the uncertainty about the effects of surgery. Recently, some large randomised trials have appeared in the literature but the controversy over its role continues. This is an update of a Cochrane review first published in 1997, and previously updated in 1999.

To assess the effects of surgery plus routine medical management, compared with routine medical management alone, in patients with primary supratentorial intracerebral haematoma.

Search strategy
We searched the Cochrane Stroke Group Trials Register (last searched June 2007), checked reference lists of relevant articles and contacted authors of relevant trials. In addition, for the original version of this review we handsearched two journals, Current Opinion in Neurology and Neurosurgery, and Neurosurgical Clinics of North America (1991 to July 1993), and three monographs. We contacted study authors for relevant information.

Selection criteria
Randomised trials of routine medical treatment plus intracranial surgery compared with routine medical treatment alone in patients with CT-confirmed primary supratentorial intracerebral haematoma. Intracranial surgery included craniotomy, stereotactic endoscopic evacuation or stereotactic aspiration.

Data collection and analysis
Two review authors independently applied the inclusion criteria, assessed trial quality and extracted the data.

Main results
Ten trials with 2059 participants were included. The quality of most of the trials was acceptable but not high. Because of this and as the overall result was sensitive to the losses to follow up in the largest trial, the estimates of effect may not be robust and may be subject to bias. Surgery was associated with statistically significant reduction in the odds of being dead or dependent at final follow up (odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58 to 0.88; 2P = 0.001) with no significant heterogeneity among the study results. Surgery was also associated with significant reduction in the odds of death at final follow up (OR 0.74, 95% CI 0.61 to 0.90; 2P = 0.003); however, there was significant heterogeneity for death as outcome.

Authors’ conclusions
In patients with CT-proven primary supratentorial intracerebral haemorrhage, surgery added to medical management reduces the odds of being dead or dependent compared with medical management alone, but the result is not very robust. Hence, further randomised trials to identify which patients benefit from surgery and to evaluate less invasive methods are indicated.


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