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Treatment of Warfarin-Related Intracranial Hemorrhage: A Comparison of Prothrombin Complex Concentrate and Recombinant Activated Factor VII
Publication year: 2010
Source: World Neurosurgery, Volume 74, Issue 6, December 2010, Pages 631-635
Nathan A., Pinner , April C., Hurdle , Carrie, Oliphant , Anne, Reaves , Bob, Lobo , …
Objective: Warfarin-related intracranial hemorrhage (ICH) is a devastating complication of warfarin therapy. Several studies have demonstrated successful correction of the international normalized ratio (INR) using prothrombin complex concentrate (PCC) or recombinant activated factor VII (rFVIIa). To our knowledge, no study has directly compared these agents for treatment of warfarin-related ICH. Methods: We retrospectively reviewed the charts of 15 patients who received rFVIIa and 9 who received PCC for treatment of warfarin-related ICH over a 2-year period. The primary objective was to compare the efficacy of rFVIIa and PCC in correcting the INR to 1.3 or less. Baseline INR was compared to INR obtained…
