Hoshino, Masatoshi MD, PhD*; Tsujio, Tadao MD, PhD*; Terai, Hidetomi MD, PhD†; Namikawa, Takashi MD, PhD†; Kato, Minori MD, PhD†; Matsumura, Akira MD, PhD†; Suzuki, Akinobu MD, PhD†; Takayama, Kazushi MD, PhD†; Takaoka, Kunio MD, PhD*; Nakamura, Hiroaki MD, PhD† Abstract Study Design. Prospective multicenter study. Objective. To examine whether initial conservative treatment interventions for [...]

Adriane Gröger1, Benjamin Bender2, Isabel Wurster1, Grzegorz Lukasz Chadzynski2, Uwe Klose2, Daniela Berg1 Objectives Degeneration of dopaminergic neurons in the substantia nigra (SN) pars compacta is the primary cause of idiopathic Parkinson’s disease (iPD). In early stages of disease in particular, presentation of symptoms is non-specific leading to difficulties in differentiating between iPD and atypical [...]

Wielage, Ronald MPH*; Bansal, Megha MA*; Wilson, Kinsley PhD†; Klein, Robert MS*; Happich, Michael PhD‡ Abstract Study Design. Cost-effectiveness model from a Quebec societal perspective using meta-analyses of clinical trials. Objective. To evaluate the cost-effectiveness of duloxetine in chronic low back pain (CLBP) compared with other post–first-line oral medications. Summary of Background Data. Duloxetine has [...]

Monique H M Vlak1,2, Gabriel J E Rinkel1, Paut Greebe1, Jacoba P Greving3, Ale Algra1,3 Abstract Objective The overall incidence of aneurysmal subarachnoid haemorrhage (aSAH) in western populations is around 9 per 100 000 person-years, which confers to a lifetime risk of around half per cent. Risk factors for aSAH are usually expressed as relative risks [...]

Shen, Jianxiong MD; Wang, Zijia MD; Liu, Jiaming MD; Xue, Xuhong MD; Qiu, Guixing MD Abstract Study Design. Retrospective study of a series of 226 consecutive Chinese patients with congenital scoliosis. Objective. To identify the incidence of intraspinal abnormalities and other organ defects in surgical patients with congenital scoliosis in Chinese population. Summary of Background [...]

Psychosurgery was developed early in human prehistory (trephination) as a need perhaps to alter aberrant behavior and treat mental illness. The “American Crowbar Case” provided an impetus to study the brain and human behavior. The frontal lobe syndrome was avidly studied. Frontal lobotomy was developed in the 1930s for the treatment of mental illness and [...]

Study Design. Multicenter, randomized, patient-assessor blind, sham-controlled clinical trial. Objective. To investigate the efficacy of acupuncture treatment with individualized setting for reduction of bothersomeness in participants with chronic low back pain (cLBP). Summary of Background Data. Low back pain is one of the main reasons of disability among adults of working age. Acupuncture is known [...]

Study Design. Systematic literature review. Objective. To categorize published evidence systematically for lumbar fusion for chronic low back pain (LBP) in order to provide an updated and comprehensive analysis of the clinical outcomes. Summary of Background Data. Despite a large number of publications of outcomes of spinal fusion surgery for chronic LBP, there is little [...]

Study Design. Retrospective cohort study using national health insurance data. Objective. To provide a longitudinal reoperation rate after surgery for lumbar herniated intervertebral disc (HIVD) disease, and to compare the reoperation rates of surgical methods. Summary of Background Data. Herniated intervertebral disc disease is the most common cause of lumbar spinal surgery. Despite improved surgical [...]

We describe a case of spontaneous spinal extradural haematoma presenting as cardiac chest pain. Although a neurosurgical emergency, the diagnosis is initially missed until neurological deficit develops. Prompt MRI scans of the spine followed by rapid transfer to a neurosurgical unit for definitive intervention increase the chances of full recovery. http://www.unboundmedicine.com/medline/citation/23565973/Spontaneous_spinal_extradural_haematoma_presenting_as_cardiac_chest_pain_