No significant difference between chiari malformation type 1.5 and type I.

Clin Neurol Neurosurg. 2017 Jun;157:34-39. doi: 10.1016/j.clineuro.2017.03.024. Epub 2017 Mar 30.

No significant difference between chiari malformation type 1.5 and type I.

Abstract

OBJECTIVE:

Chiari malformation Type 1.5 (CM 1.5) was defined as the association of Chiari malformation Type I (CM I) and brainstem herniation. The objective was to demonstrate the difference of clinical features and surgical outcomes between CM 1.5 and CM I.

PATIENTS AND METHODS:

All CM 1.5 and CM I adult patients who underwent posterior fossa decompression with duraplasty at our institution between 2006 and 2010 were retrospectively reviewed. Clinical characteristics, imaging features, and long-term outcomes were compared between CM 1.5 and CM I patients.

RESULTS:

A total of 142 adult patients were enrolled, including 27 CM 1.5 and 115 CM I patients. The average follow-up period was 102 months. Age at diagnosis was significantly younger in CM 1.5 group than CM I group (p=0.039). And the degree of tonsillar herniation was significantly more severe in CM 1.5 group than CM I group (p<0.001). There was no significant difference in other clinical and imaging characteristics. Moreover, improvement of symptoms was observed in 21 CM 1.5 patients (77.8%) and 94 CM I patients (81.7%), and no significant difference was detected (p=0.637). There was no significant difference in the resolution of syringomyelia between CM 1.5 (72.7%) and CM I (76.5%) patients, either (p=0. 710).

CONCLUSIONS:

Although CM 1.5 patients presented with brainstem herniation and more severe tonsillar herniation, other clinical and imaging features and surgical outcomes were similar with CM I patients. We think CM 1.5 is just a subtype of CM I, rather than a unique typeof Chiari malformations.

KEYWORDS:

Brainstem herniation; Chiari malformation; Posterior cranial fossa; Syringomeylia; Tonsillar ectopia

PMID:

 

28384597

 

DOI:

 

10.1016/j.clineuro.2017.03.024


Categories: Neurosurgery General

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